FTY720, a sphingosine-1-phosphate (S1P) analog, is used as an immune modulator for the treatment of multiple sclerosis. Collecting evidence has suggested mode of action of FTY720 independent of S1P modulators. In fission yeast, FTY720 induces increased levels of intracellular Ca2 + and ROS. We have previously identified 49 genes that lead to the elimination of FTY720 sensitivity.
Here, we characterized the mutant FTY720-sensitive in terms of its relevance to Ca2 + homeostasis and identified 16 FTY720- and Ca2 + – sensitive mutant (mutant FCS). Most of FTY720-sensitive mutants showed increased Ca2 + levels and exhibited Ca2 + dysregulation by FTY720 treatment. One functional category between a gene deletion makes the cells vulnerable to FTY720 and Ca2 + including membrane trafficking Golgi / endosomal.
Specifically, FTY720, but not phosphorylated FTY720 able to stimulate Ca2 + increase, inhibit secretion of acid phosphatase in wild type cells. Importantly, defective secretion of Golgi / endosomal trafficking mutants, Vps45, or Ryh1 deletion, which is further exacerbated by FTY720. Our FCS screen also identified a mutant protein adenylyl cyclase CAP1 related and homologous Rictor Ste20, the real elimination of aggravated decrease secretion of FTY720-sensitive. Collectively, our data may suggest the synergistic effects of FTY720 in combination with interference on proliferation and secretion of Ca2 + homeostasis.
Chemical genetic analysis of FTY720- and Ca 2+ -sensitive mutants reveals a functional connection between FTY720 and membrane trafficking
Chemical and Microstructural Characterization of pH and [Ca 2+] Dependent Sol-Gel Transition in mucin Biopolymers
Mucus is responsible for controlling the transport and barrier function in biological systems, and its properties can be significantly influenced by changes in the composition and the environment. In this study, the effects of pH and CaCl2 checked on the transition-to-gel solution of mucin, the main structural component of mucus. micro structural changes that correlate with macroscale viscoelastic behavior as a function of pH and adding calcium to use rheology, dynamic light scattering, zeta potential, surface tension, and FTIR spectroscopic characterization. mucin solution switched from the solution to the behavior of gel between pH 4-5 and correspondingly shown an increase of more than tenfold viscoelastic modulus.
Addition of CaCl2 increase the sol-gel transition to a pH value of ca. 6, with a two-fold increase in the loss modulus at low frequencies and a tenfold increase in storage modulus. Changing special ionic conditions [H +] and [Ca2 +] -modulated sol-gel transition pH, isoelectric point, and the viscoelastic propertie s for such reversible conformational changes with mucin form a network structure via non-covalent cross-links between chains of mucin.
efficient strategies in enhancing sensitivity important for ultrasensitive detection of tumor markers. In this work, based on a strategy of chemical adsorption-assisted label conversion triggered electroactivity sensing interface, the Ag / AgCl were made to improve the sensitivity of built sandwich-type amperometric immunosensor for ultrasensitive detection of carbohydrate antigen 19-9 (CA19-9).
CD143 Blocking Peptide
20-abx062093
Abbexa
Anti-Hu CD143 Purified
11-796-C025
ExBio
0.025 mg
EUR 118.8
Anti-Hu CD143 Purified
11-796-C100
ExBio
0.1 mg
EUR 189.6
Anti-Hu CD143 PE
1P-796-T025
ExBio
25 tests
EUR 168
Anti-Hu CD143 PE
1P-796-T100
ExBio
100 tests
EUR 288
Angiotensin-Converting Enzyme (CD143) Antibody
20-abx007531
Abbexa
EUR 360.00
EUR 526.80
EUR 226.80
Angiotensin-Converting Enzyme (CD143) Antibody
abx413653-1ml
Abbexa
1 ml
EUR 1228.8
Angiotensin-Converting Enzyme (CD143) Antibody (FITC)
abx413654-01mg
Abbexa
0.1 mg
EUR 693.6
Mouse Anti Human Cd143 Monoclonal Antibody,Biotin
CABT-47052MH
Creative Diagnostics
0.1 mg
EUR 889.2
Purified Anti-human CD143 Antibody *5-369*
11430000
AAT Bioquest
100 ug
EUR 365
APC Anti-human CD143 Antibody *5-369*
114301B0
AAT Bioquest
25 tests
EUR 383
APC Anti-human CD143 Antibody *5-369*
114301B1
AAT Bioquest
100 tests
EUR 995
APC Anti-human CD143 Antibody *5-369*
114301B2
AAT Bioquest
500 tests
EUR 2984
FITC Anti-human CD143 Antibody *5-369*
114301G0
AAT Bioquest
100 tests
EUR 547
FITC Anti-human CD143 Antibody *5-369*
114301G1
AAT Bioquest
500 tests
EUR 2051
TRITC Anti-human CD143 Antibody *5-369*
114301H0
AAT Bioquest
100 tests
EUR 547
TRITC Anti-human CD143 Antibody *5-369*
114301H1
AAT Bioquest
500 tests
EUR 2051
PacBlue Anti-human CD143 Antibody *5-369*
114301I0
AAT Bioquest
100 tests
EUR 547
PacBlue Anti-human CD143 Antibody *5-369*
114301I1
AAT Bioquest
500 tests
EUR 2051
PacOrange Anti-human CD143 Antibody *5-369*
114301J0
AAT Bioquest
100 tests
EUR 547
PacOrange Anti-human CD143 Antibody *5-369*
114301J1
AAT Bioquest
500 tests
EUR 2051
PE Anti-human CD143 Antibody *5-369*
114301K0
AAT Bioquest
25 tests
EUR 383
PE Anti-human CD143 Antibody *5-369*
114301K1
AAT Bioquest
100 tests
EUR 995
PE Anti-human CD143 Antibody *5-369*
114301K2
AAT Bioquest
500 tests
EUR 2984
PerCP Anti-human CD143 Antibody *5-369*
114301S0
AAT Bioquest
25 tests
EUR 383
PerCP Anti-human CD143 Antibody *5-369*
114301S1
AAT Bioquest
100 tests
EUR 995
PerCP Anti-human CD143 Antibody *5-369*
114301S2
AAT Bioquest
500 tests
EUR 2984
APC/Cy7 Anti-human CD143 Antibody *5-369*
114301C0
AAT Bioquest
25 tests
EUR 429
APC/Cy7 Anti-human CD143 Antibody *5-369*
114301C1
AAT Bioquest
100 tests
EUR 1117
APC/Cy7 Anti-human CD143 Antibody *5-369*
114301C2
AAT Bioquest
500 tests
EUR 3351
PE/Cy5 Anti-human CD143 Antibody *5-369*
114301L0
AAT Bioquest
25 tests
EUR 429
PE/Cy5 Anti-human CD143 Antibody *5-369*
114301L1
AAT Bioquest
100 tests
EUR 1117
PE/Cy5 Anti-human CD143 Antibody *5-369*
114301L2
AAT Bioquest
500 tests
EUR 3351
PE/Cy7 Anti-human CD143 Antibody *5-369*
114301M0
AAT Bioquest
25 tests
EUR 429
PE/Cy7 Anti-human CD143 Antibody *5-369*
114301M1
AAT Bioquest
100 tests
EUR 1117
PE/Cy7 Anti-human CD143 Antibody *5-369*
114301M2
AAT Bioquest
500 tests
EUR 3351
PerCP/Cy5.5 Anti-human CD143 Antibody *5-369*
114301T0
AAT Bioquest
25 tests
EUR 429
PerCP/Cy5.5 Anti-human CD143 Antibody *5-369*
114301T1
AAT Bioquest
100 tests
EUR 1117
PerCP/Cy5.5 Anti-human CD143 Antibody *5-369*
114301T2
AAT Bioquest
500 tests
EUR 3351
iFluor® 350 Anti-human CD143 Antibody *5-369*
11430010
AAT Bioquest
100 tests
EUR 547
iFluor® 350 Anti-human CD143 Antibody *5-369*
11430011
AAT Bioquest
500 tests
EUR 2051
iFluor® 405 Anti-human CD143 Antibody *5-369*
11430020
AAT Bioquest
100 tests
EUR 547
iFluor® 405 Anti-human CD143 Antibody *5-369*
11430021
AAT Bioquest
500 tests
EUR 2051
iFluor® 430 Anti-human CD143 Antibody *5-369*
11430030
AAT Bioquest
100 tests
EUR 547
iFluor® 430 Anti-human CD143 Antibody *5-369*
11430031
AAT Bioquest
500 tests
EUR 2051
iFluor® 450 Anti-human CD143 Antibody *5-369*
11430040
AAT Bioquest
100 tests
EUR 547
iFluor® 450 Anti-human CD143 Antibody *5-369*
11430041
AAT Bioquest
500 tests
EUR 2051
iFluor® 488 Anti-human CD143 Antibody *5-369*
11430050
AAT Bioquest
100 tests
EUR 547
iFluor® 488 Anti-human CD143 Antibody *5-369*
11430051
AAT Bioquest
500 tests
EUR 2051
iFluor® 514 Anti-human CD143 Antibody *5-369*
11430060
AAT Bioquest
100 tests
EUR 547
iFluor® 514 Anti-human CD143 Antibody *5-369*
11430061
AAT Bioquest
500 tests
EUR 2051
iFluor® 532 Anti-human CD143 Antibody *5-369*
11430070
AAT Bioquest
100 tests
EUR 547
iFluor® 532 Anti-human CD143 Antibody *5-369*
11430071
AAT Bioquest
500 tests
EUR 2051
iFluor® 546 Anti-human CD143 Antibody *5-369*
11430080
AAT Bioquest
100 tests
EUR 547
iFluor® 546 Anti-human CD143 Antibody *5-369*
11430081
AAT Bioquest
500 tests
EUR 2051
iFluor® 555 Anti-human CD143 Antibody *5-369*
11430090
AAT Bioquest
100 tests
EUR 547
iFluor® 555 Anti-human CD143 Antibody *5-369*
11430091
AAT Bioquest
500 tests
EUR 2051
iFluor® 560 Anti-human CD143 Antibody *5-369*
114300A0
AAT Bioquest
100 tests
EUR 547
iFluor® 560 Anti-human CD143 Antibody *5-369*
114300A1
AAT Bioquest
500 tests
EUR 2051
iFluor® 568 Anti-human CD143 Antibody *5-369*
114300B0
AAT Bioquest
100 tests
EUR 547
iFluor® 568 Anti-human CD143 Antibody *5-369*
114300B1
AAT Bioquest
500 tests
EUR 2051
iFluor® 594 Anti-human CD143 Antibody *5-369*
114300C0
AAT Bioquest
100 tests
EUR 547
iFluor® 594 Anti-human CD143 Antibody *5-369*
114300C1
AAT Bioquest
500 tests
EUR 2051
iFluor® 610 Anti-human CD143 Antibody *5-369*
114300D0
AAT Bioquest
100 tests
EUR 547
iFluor® 610 Anti-human CD143 Antibody *5-369*
114300D1
AAT Bioquest
500 tests
EUR 2051
iFluor® 633 Anti-human CD143 Antibody *5-369*
114300E0
AAT Bioquest
100 tests
EUR 547
iFluor® 633 Anti-human CD143 Antibody *5-369*
114300E1
AAT Bioquest
500 tests
EUR 2051
iFluor® 647 Anti-human CD143 Antibody *5-369*
114300F0
AAT Bioquest
100 tests
EUR 547
iFluor® 647 Anti-human CD143 Antibody *5-369*
114300F1
AAT Bioquest
500 tests
EUR 2051
iFluor® 660 Anti-human CD143 Antibody *5-369*
114300G0
AAT Bioquest
100 tests
EUR 547
iFluor® 660 Anti-human CD143 Antibody *5-369*
114300G1
AAT Bioquest
500 tests
EUR 2051
iFluor® 670 Anti-human CD143 Antibody *5-369*
114300H0
AAT Bioquest
100 tests
EUR 547
iFluor® 670 Anti-human CD143 Antibody *5-369*
114300H1
AAT Bioquest
500 tests
EUR 2051
iFluor® 680 Anti-human CD143 Antibody *5-369*
114300I0
AAT Bioquest
100 tests
EUR 547
iFluor® 680 Anti-human CD143 Antibody *5-369*
114300I1
AAT Bioquest
500 tests
EUR 2051
iFluor® 700 Anti-human CD143 Antibody *5-369*
114300J0
AAT Bioquest
100 tests
EUR 547
iFluor® 700 Anti-human CD143 Antibody *5-369*
114300J1
AAT Bioquest
500 tests
EUR 2051
iFluor® 710 Anti-human CD143 Antibody *5-369*
114300K0
AAT Bioquest
100 tests
EUR 547
iFluor® 710 Anti-human CD143 Antibody *5-369*
114300K1
AAT Bioquest
500 tests
EUR 2051
iFluor® 750 Anti-human CD143 Antibody *5-369*
114300L0
AAT Bioquest
100 tests
EUR 547
iFluor® 750 Anti-human CD143 Antibody *5-369*
114300L1
AAT Bioquest
500 tests
EUR 2051
iFluor® 790 Anti-human CD143 Antibody *5-369*
114300M0
AAT Bioquest
100 tests
EUR 547
iFluor® 790 Anti-human CD143 Antibody *5-369*
114300M1
AAT Bioquest
500 tests
EUR 2051
iFluor® 800 Anti-human CD143 Antibody *5-369*
114300N0
AAT Bioquest
100 tests
EUR 547
iFluor® 800 Anti-human CD143 Antibody *5-369*
114300N1
AAT Bioquest
500 tests
EUR 2051
iFluor® 810 Anti-human CD143 Antibody *5-369*
114300O0
AAT Bioquest
100 tests
EUR 547
iFluor® 810 Anti-human CD143 Antibody *5-369*
114300O1
AAT Bioquest
500 tests
EUR 2051
iFluor® 820 Anti-human CD143 Antibody *5-369*
114300P0
AAT Bioquest
100 tests
EUR 547
iFluor® 820 Anti-human CD143 Antibody *5-369*
114300P1
AAT Bioquest
500 tests
EUR 2051
iFluor® 840 Anti-human CD143 Antibody *5-369*
114300Q0
AAT Bioquest
100 tests
EUR 547
iFluor® 840 Anti-human CD143 Antibody *5-369*
114300Q1
AAT Bioquest
500 tests
EUR 2051
iFluor® 860 Anti-human CD143 Antibody *5-369*
114300R0
AAT Bioquest
100 tests
EUR 547
iFluor® 860 Anti-human CD143 Antibody *5-369*
114300R1
AAT Bioquest
500 tests
EUR 2051
iFluor® A7 Anti-human CD143 Antibody *5-369*
114300S0
AAT Bioquest
100 tests
EUR 547
iFluor® A7 Anti-human CD143 Antibody *5-369*
114300S1
AAT Bioquest
500 tests
EUR 2051
mFluor™ UV375 Anti-human CD143 Antibody *5-369*
114300X0
AAT Bioquest
100 tests
EUR 547
mFluor™ UV375 Anti-human CD143 Antibody *5-369*
114300X1
AAT Bioquest
500 tests
EUR 2051
mFluor™ UV460 Anti-human CD143 Antibody *5-369*
114300Y0
AAT Bioquest
100 tests
EUR 547
mFluor™ UV460 Anti-human CD143 Antibody *5-369*
114300Y1
AAT Bioquest
500 tests
EUR 2051
mFluor™ Blue 570 Anti-human CD143 Antibody *5-369*
114300T0
AAT Bioquest
100 tests
EUR 547
mFluor™ Blue 570 Anti-human CD143 Antibody *5-369*
114300T1
AAT Bioquest
500 tests
EUR 2051
mFluor™ Green 620 Anti-human CD143 Antibody *5-369*
114300U0
AAT Bioquest
100 tests
EUR 547
mFluor™ Green 620 Anti-human CD143 Antibody *5-369*
114300U1
AAT Bioquest
500 tests
EUR 2051
mFluor™ Red 700 Anti-human CD143 Antibody *5-369*
114300V0
AAT Bioquest
100 tests
EUR 547
mFluor™ Red 700 Anti-human CD143 Antibody *5-369*
114300V1
AAT Bioquest
500 tests
EUR 2051
mFluor™ Red 780 Anti-human CD143 Antibody *5-369*
114300W0
AAT Bioquest
100 tests
EUR 547
mFluor™ Red 780 Anti-human CD143 Antibody *5-369*
114300W1
AAT Bioquest
500 tests
EUR 2051
mFluor™ Violet 450 Anti-human CD143 Antibody *5-369*
114300Z0
AAT Bioquest
100 tests
EUR 547
mFluor™ Violet 450 Anti-human CD143 Antibody *5-369*
114300Z1
AAT Bioquest
500 tests
EUR 2051
mFluor™ Violet 500 Anti-human CD143 Antibody *5-369*
11430100
AAT Bioquest
100 tests
EUR 547
mFluor™ Violet 500 Anti-human CD143 Antibody *5-369*
11430101
AAT Bioquest
500 tests
EUR 2051
mFluor™ Violet 510 Anti-human CD143 Antibody *5-369*
11430110
AAT Bioquest
100 tests
EUR 547
mFluor™ Violet 510 Anti-human CD143 Antibody *5-369*
11430111
AAT Bioquest
500 tests
EUR 2051
mFluor™ Violet 540 Anti-human CD143 Antibody *5-369*
11430120
AAT Bioquest
100 tests
EUR 547
mFluor™ Violet 540 Anti-human CD143 Antibody *5-369*
11430121
AAT Bioquest
500 tests
EUR 2051
APC/iFluor® 700 Anti-human CD143 Antibody *5-369*
114301E0
AAT Bioquest
25 tests
EUR 429
APC/iFluor® 700 Anti-human CD143 Antibody *5-369*
114301E1
AAT Bioquest
100 tests
EUR 1117
APC/iFluor® 700 Anti-human CD143 Antibody *5-369*
114301E2
AAT Bioquest
500 tests
EUR 3351
APC/iFluor® 750 Anti-human CD143 Antibody *5-369*
114301F0
AAT Bioquest
25 tests
EUR 429
APC/iFluor® 750 Anti-human CD143 Antibody *5-369*
114301F1
AAT Bioquest
100 tests
EUR 1117
APC/iFluor® 750 Anti-human CD143 Antibody *5-369*
114301F2
AAT Bioquest
500 tests
EUR 3351
PE/iFluor® 647 Anti-human CD143 Antibody *5-369*
114301P0
AAT Bioquest
25 tests
EUR 429
PE/iFluor® 647 Anti-human CD143 Antibody *5-369*
114301P1
AAT Bioquest
100 tests
EUR 1117
PE/iFluor® 647 Anti-human CD143 Antibody *5-369*
114301P2
AAT Bioquest
500 tests
EUR 3351
PE/iFluor® 750 Anti-human CD143 Antibody *5-369*
114301Q0
AAT Bioquest
25 tests
EUR 429
PE/iFluor® 750 Anti-human CD143 Antibody *5-369*
114301Q1
AAT Bioquest
100 tests
EUR 1117
PE/iFluor® 750 Anti-human CD143 Antibody *5-369*
114301Q2
AAT Bioquest
500 tests
EUR 3351
PE/Texas Red® Anti-human CD143 Antibody *5-369*
114301R0
AAT Bioquest
25 tests
EUR 429
PE/Texas Red® Anti-human CD143 Antibody *5-369*
114301R1
AAT Bioquest
100 tests
EUR 1117
PE/Texas Red® Anti-human CD143 Antibody *5-369*
114301R2
AAT Bioquest
500 tests
EUR 3351
PE/iFluor® 700 Anti-human CD143 Antibody *5-369*
114301U0
AAT Bioquest
25 tests
EUR 429
PE/iFluor® 700 Anti-human CD143 Antibody *5-369*
114301U1
AAT Bioquest
100 tests
EUR 1117
PE/iFluor® 700 Anti-human CD143 Antibody *5-369*
114301U2
AAT Bioquest
500 tests
EUR 3351
PE/iFluor® 594 Anti-human CD143 Antibody *5-369*
114301Y0
AAT Bioquest
25 tests
EUR 429
PE/iFluor® 594 Anti-human CD143 Antibody *5-369*
114301Y1
AAT Bioquest
100 tests
EUR 1117
PE/iFluor® 594 Anti-human CD143 Antibody *5-369*
114301Y2
AAT Bioquest
500 tests
EUR 3351
XFD350 Anti-human CD143 Antibody *5-369, XFD350 Same Structure to Alexa Fluor™ 350*
11430130
AAT Bioquest
100 tests
EUR 547
XFD350 Anti-human CD143 Antibody *5-369, XFD350 Same Structure to Alexa Fluor™ 350*
11430131
AAT Bioquest
500 tests
EUR 2051
XFD488 Anti-human CD143 Antibody *5-369, XFD488 Same Structure to Alexa Fluor™ 488*
11430140
AAT Bioquest
100 tests
EUR 547
XFD488 Anti-human CD143 Antibody *5-369, XFD488 Same Structure to Alexa Fluor™ 488*
11430141
AAT Bioquest
500 tests
EUR 2051
XFD555 Anti-human CD143 Antibody *5-369, XFD555 Same Structure to Alexa Fluor™ 555*
11430150
AAT Bioquest
100 tests
EUR 547
XFD555 Anti-human CD143 Antibody *5-369, XFD555 Same Structure to Alexa Fluor™ 555*
11430151
AAT Bioquest
500 tests
EUR 2051
XFD594 Anti-human CD143 Antibody *5-369, XFD594 Same Structure to Alexa Fluor™ 594*
11430160
AAT Bioquest
100 tests
EUR 547
XFD594 Anti-human CD143 Antibody *5-369, XFD594 Same Structure to Alexa Fluor™ 594*
11430161
AAT Bioquest
500 tests
EUR 2051
XFD647 Anti-human CD143 Antibody *5-369, XFD647 Same Structure to Alexa Fluor™ 647*
11430170
AAT Bioquest
100 tests
EUR 547
XFD647 Anti-human CD143 Antibody *5-369, XFD647 Same Structure to Alexa Fluor™ 647*
11430171
AAT Bioquest
500 tests
EUR 2051
XFD680 Anti-human CD143 Antibody *5-369, XFD680 Same Structure to Alexa Fluor™ 680*
11430180
AAT Bioquest
100 tests
EUR 547
XFD680 Anti-human CD143 Antibody *5-369, XFD680 Same Structure to Alexa Fluor™ 680*
11430181
AAT Bioquest
500 tests
EUR 2051
XFD700 Anti-human CD143 Antibody *5-369, XFD700 Same Structure to Alexa Fluor™ 700*
11430190
AAT Bioquest
100 tests
EUR 547
XFD700 Anti-human CD143 Antibody *5-369, XFD700 Same Structure to Alexa Fluor™ 700*
11430191
AAT Bioquest
500 tests
EUR 2051
XFD750 Anti-human CD143 Antibody *5-369, XFD750 Same Structure to Alexa Fluor™ 750*
114301A0
AAT Bioquest
100 tests
EUR 547
XFD750 Anti-human CD143 Antibody *5-369, XFD750 Same Structure to Alexa Fluor™ 750*
114301A1
AAT Bioquest
500 tests
EUR 2051
APC/XFD750 Anti-human CD143 Antibody *5-369, XFD750 Same Structure to Alexa Fluor™ 750*
114301D0
AAT Bioquest
25 tests
EUR 429
APC/XFD750 Anti-human CD143 Antibody *5-369, XFD750 Same Structure to Alexa Fluor™ 750*
114301D1
AAT Bioquest
100 tests
EUR 1117
APC/XFD750 Anti-human CD143 Antibody *5-369, XFD750 Same Structure to Alexa Fluor™ 750*
114301D2
AAT Bioquest
500 tests
EUR 3351
PE/XFD610 Anti-human CD143 Antibody *5-369, XFD610 Same Structure to Alexa Fluor™ 610*
114301N0
AAT Bioquest
25 tests
EUR 429
PE/XFD610 Anti-human CD143 Antibody *5-369, XFD610 Same Structure to Alexa Fluor™ 610*
114301N1
AAT Bioquest
100 tests
EUR 1117
Briefly, polydopamine-Ag nanoparticles (Ag NP PDA), a precursor signal, combined with labeled antibody served as a label and melamine graphene oxide (GO-MA) substrate with the absorption capacity of the chemicals applied as intelligent sensing interface. After a successful incubation label, there is no response primitive at this time because of poor conductivity between the label and the electrodes. However, the presence of H2O2, Ag NP of labels can be engraved Ag ions, which are absorbed by the GO-MA to establish GO-MA-Ag as electroactive substrates.