Diffusivity in the A- and B-sites CaMnO3 polycrystalline perovskite-δ-deficient Ca and spinel CaMn2O4 (marokite) as a secondary phase was studied using chemical tracers and secondary ion mass spectrometry (SIMS) equipped with electron probe microanalysis (EPMA). a thin film containing a chemical tracer Sr and Co is deposited on the polished surface of the polycrystalline composite samples followed by annealing at 800-1200 ° C for 96 hours. diffusion profile for each tracker is determined by SIMS, followed by calculation of the diffusion coefficient by fitting to the appropriate model.

Trackers Sr showed diffusion especially grating, with the activation energy of 210 ± 30 kJ mol-1, while the Co tracker shows the combination of lattice and enhanced grain boundary diffusion, with an activation energy of 270 ± 30 kJ mol-1 and 380 ± 40 kJ mol-1, each

The diffusivity can be used to predict the lifetime of the interdiffusion and the junctions between the n-type or CaMnO3 CaMnO3-δ-δ / CaMn2O4 composite and interlayers metallization or p-type material in the leg oxide thermoelectrics. In particular, relatively high diffusivity in polycrystalline CaMnO3 effective co-δ may play a role in reporting the rapid formation of a secondary phase (Ca3Co2-yMnyO6) between Ca3Co3.92O9 + p-type and n-type δ-δ CaMnO3 in a direct pn junction thermoelectric ,
A quick search in the database of scientific publications have demonstrated how the use of CRISPR-Cas genome engineering has considerably expanded edition, and growing importance, in modern molecular biology. Only in pub-med Platform, the search term gives more than 3000 results.

In particular, in Drug Discovery, Medicinal Chemistry and Chemical Biology in general CRISPR method may have multiple applications. Some of these applications are: resistance-election study of organic compounds lead antimalarial; druggability investigation; the development of animal models to test chemical compounds, etc. In this paper, we offer a review of the relevant scientific literature illustrated with specific examples of the application of CRISPR techniques for medicinal chemistry and chemical biology. We also present a general overview of the main trends regarding legal and ethical methods of genome editing.

active modulation of carbonate chemistry calcifying fluid (δ11B, B / Ca) and seasonal invariant coral calcification in the sub-tropical boundary.

Coral calcification depends on both the supply of dissolved inorganic carbon (DIC) and the up-regulation of pH on calcifying fluid (cf). Using geochemical proxies (δ11B, B / Ca, Sr / Ca, Li / Mg), we show seasonal changes in pHcf and DICcf ​​to Acropora yongei and Pocillopora damicornis grown in-situ on Rottnest Island (32 ° S) in Western Australia , Changes in pHcf span of 8:38 in the summer to 8.60 in the winter, while DICcf ​​is 25 to 30% higher during the summer than the winter (× 1.5 × 2 to the sea). Thus, the two variables is up-regulated far above the values ​​of seawater and seasonal out of phase with each other.

BACE1
MBS8534951-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

BACE1
MBS8534951-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

BACE1
MBS8534951-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

BACE1
MBS556383-005mg	MyBiosource	0.05mg	EUR 500

BACE1
MBS556383-5x005mg	MyBiosource	5x0.05mg	EUR 2100

bACE1 siRNA
20-abx908826	Abbexa	Ask for price Ask for price	15 nmol 30 nmol

bACE1 siRNA
20-abx908827	Abbexa	Ask for price Ask for price	15 nmol 30 nmol

bACE1 siRNA
20-abx900582	Abbexa	Ask for price Ask for price	15 nmol 30 nmol

BACE1 protein
E62B011	EnoGene	20ug	EUR 225

BACE1 protein
MBS8574980-002mg	MyBiosource	0.02mg	EUR 305

BACE1 protein
MBS8574980-5x002mg	MyBiosource	5x0.02mg	EUR 1220

BACE1 Antibody
6651-100	Biovision	each	EUR 418.8

BACE1 Antibody
6651-30T	Biovision	each	EUR 175.2

BACE1 antibody
20R-BR014	Fitzgerald	50 ug	EUR 709
Description: Rabbit polyclonal BACE1 antibody

BACE1 antibody
20R-BR015	Fitzgerald	50 ug	EUR 709
Description: Rabbit polyclonal BACE1 antibody

BACE1 Antibody
35650	SAB	100ul	EUR 319

BACE1 Antibody
35650-100ul	SAB	100ul	EUR 302.4

BACE1 Antibody
E035650	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

BACE1 Antibody
E10-30625	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

BACE1 Antibody
E10-30625T	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

BACE1 Antibody
E19-7939-1	EnoGene	50ug/50ul	EUR 145
Description: Available in various conjugation types.

BACE1 Antibody
E19-7939-2	EnoGene	100ug/100ul	EUR 225
Description: Available in various conjugation types.

BACE1 Antibody
DF7939	Affbiotech	200ul	EUR 420

BACE1 Antibody
DF7939-100ul	Affinity Biosciences	100ul	EUR 280

BACE1 Antibody
DF7939-200ul	Affinity Biosciences	200ul	EUR 350

BACE1 antibody
E39-10412	EnoGene	100ug/100ul	EUR 225
Description: Available in various conjugation types.

BACE1 Antibody
E305133	EnoGene	100ug/200ul	EUR 275
Description: Available in various conjugation types.

BACE1 Antibody
E307287	EnoGene	100ug/200ul	EUR 275
Description: Available in various conjugation types.

BACE1 antibody
70R-15953	Fitzgerald	50 ul	EUR 289
Description: Rabbit polyclonal BACE1 antibody

BACE1 antibody
70R-7276	Fitzgerald	50 ug	EUR 467
Description: Rabbit polyclonal BACE1 antibody raised against the N terminal of BACE1

Bace1 antibody
70R-8662	Fitzgerald	50 ug	EUR 467
Description: Affinity purified rabbit polyclonal Bace1 antibody

BACE1 Antibody
AF6650	Affbiotech	100ul	EUR 420

BACE1 Antibody
AF6650-100ul	Affinity Biosciences	100ul	EUR 280

BACE1 Antibody
AF6650-200ul	Affinity Biosciences	200ul	EUR 350

BACE1 Antibody
1-CSB-PA008418	Cusabio	Ask for price Ask for price	100ug 50ug
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000

BACE1 Antibody
1-CSB-PA150463	Cusabio	Ask for price Ask for price	100ul 50ul
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:2000-1:5000, WB:1:500-1:2000

BACE1 Antibody
1-CSB-PA173556	Cusabio	Ask for price Ask for price	100ul 50ul
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:15-1:50

BACE1 Antibody
1-CSB-PA002524GA01HU	Cusabio	Ask for price Ask for price	150ul 50ul
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

BACE1 Antibody
1-CSB-PA002524LA01HU	Cusabio	Ask for price Ask for price	100ug 50ug
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

BACE1 Antibody
ABD7939	Nova Lifetech	100ug	EUR 325

BACE1 Antibody
ABD7999	Nova Lifetech	100ug	EUR 325

BACE1 Antibody
F50757-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.

BACE1 Antibody
F50758-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. [UniProt]

BACE1 Antibody
F50758-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. [UniProt]

Bace1 Antibody
GWB-MQ588C	GenWay Biotech	50ug	Ask for price

BACE1 Antibody
GWB-MQ589D	GenWay Biotech	50ug	Ask for price

BACE1 Antibody
MBS7136510-005mL	MyBiosource	0.05mL	EUR 220

BACE1 Antibody
MBS7136510-01mL	MyBiosource	0.1mL	EUR 300

BACE1 Antibody
MBS7136510-5x01mL	MyBiosource	5x0.1mL	EUR 1350

BACE1 Antibody
MBS7123393-005mL	MyBiosource	0.05mL	EUR 190

BACE1 Antibody
MBS7123393-01mL	MyBiosource	0.1mL	EUR 270

BACE1 Antibody
MBS7123393-5x01mL	MyBiosource	5x0.1mL	EUR 1205

BACE1 Antibody
MBS7123394-005mL	MyBiosource	0.05mL	EUR 190

BACE1 Antibody
MBS7123394-01mL	MyBiosource	0.1mL	EUR 270

BACE1 Antibody
MBS7123394-5x01mL	MyBiosource	5x0.1mL	EUR 1205

BACE1 Antibody
MBS7047737-005mg	MyBiosource	0.05mg	EUR 190

BACE1 Antibody
MBS7047737-01mg	MyBiosource	0.1mg	EUR 270

BACE1 Antibody
MBS7047737-5x01mg	MyBiosource	5x0.1mg	EUR 1205

BACE1 Antibody
MBS7119262-005mg	MyBiosource	0.05mg	EUR 150

BACE1 Antibody
MBS7119262-01mg	MyBiosource	0.1mg	EUR 190

BACE1 Antibody
MBS7119262-5x01mg	MyBiosource	5x0.1mg	EUR 845

BACE1 Antibody
MBS9407605-01mL	MyBiosource	0.1mL	EUR 305

BACE1 Antibody
MBS9407605-5x01mL	MyBiosource	5x0.1mL	EUR 1230

BACE1 Antibody
MBS854853-01mg	MyBiosource	0.1mg	EUR 345

BACE1 Antibody
MBS854853-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

BACE1 Antibody
MBS854853-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

BACE1 Antibody
MBS854853-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

BACE1 Antibody
MBS854853-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

BACE1 Antibody
MBS8517256-005mg	MyBiosource	0.05mg	EUR 235

BACE1 Antibody
MBS8517256-01mg	MyBiosource	0.1mg	EUR 305

BACE1 Antibody
MBS8517256-01mLAF405M	MyBiosource	0.1mL(AF405M)	EUR 465

BACE1 Antibody
MBS8517256-01mLAF546	MyBiosource	0.1mL(AF546)	EUR 465

BACE1 Antibody
MBS8517256-01mLAF750	MyBiosource	0.1mL(AF750)	EUR 465

BACE1 Antibody
MBS8527259-01mg	MyBiosource	0.1mg	EUR 345

BACE1 Antibody
MBS8527259-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

BACE1 Antibody
MBS8527259-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

BACE1 Antibody
MBS8527259-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

BACE1 Antibody
MBS8527259-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

BACE1 antibody
MBS535525-005mg	MyBiosource	0.05mg	EUR 1125

BACE1 antibody
MBS535525-5x005mg	MyBiosource	5x0.05mg	EUR 4905

BACE1 antibody
MBS535570-005mg	MyBiosource	0.05mg	EUR 1125

BACE1 antibody
MBS535570-5x005mg	MyBiosource	5x0.05mg	EUR 4905

BACE1 Antibody
MBS9608457-01mL	MyBiosource	0.1mL	EUR 260

BACE1 Antibody
MBS9608457-02mL	MyBiosource	0.2mL	EUR 305

BACE1 Antibody
MBS9608457-5x02mL	MyBiosource	5x0.2mL	EUR 1220

BACE1 Antibody
MBS9613671-01mL	MyBiosource	0.1mL	EUR 260

BACE1 Antibody
MBS9613671-02mL	MyBiosource	0.2mL	EUR 305

BACE1 Antibody
MBS9613671-5x02mL	MyBiosource	5x0.2mL	EUR 1220

BACE1-IN-6
T39484-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BACE1-IN-6

BACE1-IN-6
T39484-1g	TargetMol Chemicals	1g	Ask for price
Description: BACE1-IN-6

BACE1-IN-6
T39484-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BACE1-IN-6

BACE1-IN-6
T39484-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BACE1-IN-6

BACE1-IN-6
T39484-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BACE1-IN-6

BACE1-IN-1
HY-100182	MedChemExpress	5mg	EUR 2958

BACE1-IN-1
T10450-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BACE1-IN-1

BACE1-IN-1
T10450-1g	TargetMol Chemicals	1g	Ask for price
Description: BACE1-IN-1

BACE1-IN-1
T10450-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BACE1-IN-1

BACE1-IN-1
T10450-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BACE1-IN-1

BACE1-IN-1
T10450-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BACE1-IN-1

BACE1-IN-2
T10451-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BACE1-IN-2

BACE1-IN-2
T10451-1g	TargetMol Chemicals	1g	Ask for price
Description: BACE1-IN-2

BACE1-IN-2
T10451-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BACE1-IN-2

BACE1-IN-2
T10451-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BACE1-IN-2

BACE1-IN-2
T10451-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BACE1-IN-2

BACE1-IN-4
T10452-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BACE1-IN-4

BACE1-IN-4
T10452-1g	TargetMol Chemicals	1g	Ask for price
Description: BACE1-IN-4

BACE1-IN-4
T10452-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BACE1-IN-4

BACE1-IN-4
T10452-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BACE1-IN-4

BACE1-IN-4
T10452-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BACE1-IN-4

BACE1-IN-5
T10453-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BACE1-IN-5

BACE1-IN-5
T10453-1g	TargetMol Chemicals	1g	Ask for price
Description: BACE1-IN-5

BACE1-IN-5
T10453-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BACE1-IN-5

BACE1-IN-5
T10453-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BACE1-IN-5

BACE1-IN-5
T10453-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BACE1-IN-5

BACE1-IN-8
T64074-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BACE1-IN-8

BACE1-IN-8
T64074-1g	TargetMol Chemicals	1g	Ask for price
Description: BACE1-IN-8

BACE1-IN-8
T64074-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BACE1-IN-8

BACE1-IN-8
T64074-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BACE1-IN-8

BACE1-IN-8
T64074-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BACE1-IN-8

BACE1-IN-6
MBS5799951-5mg	MyBiosource	5(mg	EUR 915

BACE1-IN-6
MBS5799951-5x5mg	MyBiosource	5x5(mg	EUR 3970

BACE1-IN-1
MBS387057-10mg	MyBiosource	10mg	EUR 4020

BACE1-IN-1
MBS387057-1mg	MyBiosource	1mg	EUR 840

BACE1-IN-1
MBS387057-5mg	MyBiosource	5mg	EUR 2400

BACE1-IN-1
MBS387057-5x10mg	MyBiosource	5x10mg	EUR 18090

BACE1-IN-4
MBS3842926-10mg	MyBiosource	10mg	EUR 810

BACE1-IN-4
MBS3842926-5mg	MyBiosource	5mg	EUR 465

BACE1-IN-4
MBS3842926-5x10mg	MyBiosource	5x10mg	EUR 3630

BACE1-IN-2
MBS3843651-10mg	MyBiosource	10mg	EUR 1905

BACE1-IN-2
MBS3843651-1mg	MyBiosource	1mg	EUR 430

BACE1-IN-2
MBS3843651-5mg	MyBiosource	5mg	EUR 1165

BACE1-IN-2
MBS3843651-5x10mg	MyBiosource	5x10mg	EUR 8565

BACE1-IN-1
MBS5766121-5mg	MyBiosource	5mg	EUR 915

BACE1-IN-1
MBS5766121-5x5mg	MyBiosource	5x5mg	EUR 3970

BACE1-IN-2
MBS5766122-5mg	MyBiosource	5mg	EUR 915

BACE1-IN-2
MBS5766122-5x5mg	MyBiosource	5x5mg	EUR 3970

BACE1-IN-4
MBS5766123-5mg	MyBiosource	5mg	EUR 915

BACE1-IN-4
MBS5766123-5x5mg	MyBiosource	5x5mg	EUR 3970

BACE1-IN-2
HY-112444	MedChemExpress	Get quote	Ask for price
Description: BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM[1].

BACE1-IN-5
HY-130244	MedChemExpress	Get quote	Ask for price
Description: BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 9.1 nM, and also inhibits cellular amyloid-β (Aβ) with an IC50 of 0.82 nM. BACE1-IN-5 has a medicinal chemistry that improves hERG inhibition and P-gp efflux[1].

BACE1-IN-8
HY-144739	MedChemExpress	Get quote	Ask for price
Description: BACE1-IN-8 (compound 70b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC50 of 3.9 µM[1].

BACE1-IN-9
HY-144741	MedChemExpress	Get quote	Ask for price
Description: BACE1-IN-9 (compound 82b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC50 of 1.2 µM[1].

BACE1-IN-4
HY-128594	MedChemExpress	Get quote	Ask for price
Description: BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease[1].

BACE1-IN-6
HY-145345	MedChemExpress	Get quote	Ask for price
Description: BACE1-IN-6 is a BACE1 inhibitor with an IC50 value of 1.5 nM.

BACE1 Mouse mAb
E2220934	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

BACE1 Mouse mAb
E2221115	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

BACE1 Assay Kit
71656	BPS Bioscience	96 rxns.	EUR 530
Description: Bace1 (β-secretase 1) is an aspartic protease that is involved in the processing of the Amyloid precursor protein (APP). Cleavage of APP by BACE1 followed by γ-secretase results in β-amyloid peptide production, which ultimately leads toxic Aβ accumulation. In Alzheimer's disease (AD), it has been widely accepted that Aβ aggregation plays a critical role in AD pathogenesis, suggesting that BACE1 could be a potential target to treat AD. The BACE1 FRET Assay Kit is designed to measure BACE1 activity for screening and profiling applications based on fluorescence resonance energy transfer (FRET) using a labeled peptide substrate (below).

BACE1-IN-12
T63867-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BACE1-IN-12

BACE1-IN-12
T63867-1g	TargetMol Chemicals	1g	Ask for price
Description: BACE1-IN-12

BACE1-IN-12
T63867-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BACE1-IN-12

BACE1-IN-12
T63867-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BACE1-IN-12

BACE1-IN-12
T63867-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BACE1-IN-12

BACE1 siRNA (Rat)
MBS8238820-15nmol	MyBiosource	15nmol	EUR 405

BACE1 siRNA (Rat)
MBS8238820-30nmol	MyBiosource	30nmol	EUR 565

BACE1 siRNA (Rat)
MBS8238820-5x30nmol	MyBiosource	5x30nmol	EUR 2450

BACE1 Mouse mAb
MBS8539320-01mL	MyBiosource	0.1mL	EUR 305

BACE1 Mouse mAb
MBS8539320-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

BACE1 Mouse mAb
MBS8539320-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

BACE1 Mouse mAb
MBS8539320-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

BACE1 Mouse mAb
MBS8539320-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

BACE1 Mouse mAb
MBS8539141-01mL	MyBiosource	0.1mL	EUR 305

BACE1 Mouse mAb
MBS8539141-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

BACE1 Mouse mAb
MBS8539141-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

BACE1 Mouse mAb
MBS8539141-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

The net effect of these counter-cyclical behavior between DICcf ​​and pHcf is that the aragonite saturation state of liquid whitewash (Ωcf) rose ~ 4 times over the values ​​of seawater and ~ 25 to 40% higher during the winter than the summer , Thus, this coral control the chemical composition of the liquid whitewash to help maintain the level of calcification throughout the year in near-constant, despite the seasonal sea water temperature of only ~ 19 ° to 24 ° C. The ability of coral to up-regulate Ωcf is a key mechanism to optimize biomineralization, and thus it is important for the future of coral calcification under high CO2 conditions.